منابع مشابه
Dominant forces in protein folding.
T e purpose of this review is to assess the nature and magnitudes of the dominant forces in protein folding. Since proteins are only marginally stable at room temperature,’ no type of molecular interaction is unimportant, and even small interactions can contribute significantly (positively or negatively) to stability (Alber, 1989a,b; Matthews, 1987a,b). However, the present review aims to ident...
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A model to describe the mechanism of conformational dynamics in secondary protein based on matter interactions is proposed. The approach deploys the lagrangian method by imposing certain symmetry breaking. The protein backbone is initially assumed to be nonlinear and represented by the Sine-Gordon equation, while the nonlinear external bosonic sources is represented by φ interaction. It is argu...
متن کاملProtein folding under mechanical forces: a physiological view.
Mechanical forces regulate the function of numerous proteins relevant to physiology. The functions and folding of proteins have been under scrutiny for decades, but it was not until recently that mechanical forces have been considered. Here, we review different techniques for studying protein folding, highlighting their physiological significance.
متن کاملSpeed limit of protein folding evidenced in secondary structure dynamics.
As the simplest and most prevalent motif of protein folding, α-helix initiation is the starting point of macromolecular complexity. In this work, helix initiation was directly measured via ultrafast temperature-jump spectroscopy on the smallest possible helix nucleus for which only the first turn is formed. The rate's dependence on sequence, length, and temperature reveals the fastest possible ...
متن کاملUsing Secondary Structure Information for Protein Folding in CLP(FD)
The protein folding problem is the problem of predicting the 3D structure of a protein when the linear sequence of aminoacids identifying it is known. In this paper we present a declarative implementation in Constrain & Generate style in CLP (FD) of the protein folding problem, for models based on face-centered cubes. We use information concerning secondary structure (and other heuristics) to s...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2019
ISSN: 1554-8929,1554-8937
DOI: 10.1021/acschembio.9b00339